The longitudinal trends in the relationship between drug-induced extrapyramidal symptoms and personal and social performance in a population of the patients with schizophrenia: A latent growth model
| Autor: | Jin-Sang Yoon, Chul Eung Kim, Dong Chung Jung, Hee-Yeon Jung, Yong Min Ahn, Samuel Suk Hyun Hwang, Yong Sik Kim, In-Jo Park |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Population Affect (psychology) 03 medical and health sciences 0302 clinical medicine Basal Ganglia Diseases Extrapyramidal symptoms Quality of life Path coefficient medicine Humans Longitudinal Studies Psychiatry education Biological Psychiatry Psychiatric Status Rating Scales education.field_of_study Reproducibility of Results Construct validity Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Cross-Sectional Studies Schizophrenia Female Schizophrenic Psychology medicine.symptom Psychology Social Adjustment Psychosocial 030217 neurology & neurosurgery Antipsychotic Agents Clinical psychology |
| Zdroj: | Psychiatry Research. 238:33-39 |
| ISSN: | 0165-1781 |
| Popis: | The aim of this study was to explore the longitudinal trends in the relationship between personal and social functioning and drug-induced extrapyramidal symptoms (DIEPS). The baseline sample included 484 patients with schizophrenia. Participants were assessed at baseline, weeks 4 (time 2), 8 (time 3), and 12 (time 4) regarding social functioning, and DIEPS. In latent growth analysis, the path coefficient between the intercept for the DIEPSS and the intercept for the PSP indicated a significant cross-sectional relationship between these two variables. And the path coefficient between the intercept of the DIEPSS and the slope of the PSP was also significant, indicating that patients who initially had more serious side effects tended to exhibit less improvement in their personal and social functioning over time. Similarly, a significant path coefficient between the slopes of the two variables indicated a dynamic and possibly reciprocal association over time. In addition, K-PSP scale showed good construct validity and reliability. Based on the standardized PSP scale, our results demonstrate DIEPSS induced by antipsychotic treatment dynamically affect personal and social functioning over time, a negative association between psychosocial aspects and the DIEPS. |
| Databáze: | OpenAIRE |
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