Epigallocatechin-3-gallate attenuates neointimal hyperplasia in a rat model of carotid artery injury by inhibition of high mobility group box 1 expression
| Autor: | Ranran Meng, Xuejun Wu, Bin Yang, Yubin Li, Jingqiang Yan, Xing Jin, Jixiang Yu, Yu Li, Peng Gao |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Neointima Cancer Research Pathology medicine.medical_specialty high mobility group box 1 Inflammation neointimal hyperplasia Pharmacology HMGB1 medicine.disease_cause complex mixtures 03 medical and health sciences Immunology and Microbiology (miscellaneous) Restenosis medicine oxidative stress heterocyclic compounds Neointimal hyperplasia biology business.industry food and beverages Articles General Medicine medicine.disease Molecular medicine 030104 developmental biology inflammation Apoptosis biology.protein epigallocatechin-3-gallate sense organs medicine.symptom business Oxidative stress |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Epigallocatechin-3-gallate (EGCG) is a kind of polyphenol compound, called catechin, and is extracted from green tea. EGCG has a wide range of biological activities. The present study aimed to evaluate the effect of EGCG on neointimal hyperplasia in a rat model of carotid artery balloon injury and to explore the molecular mechanisms involved. Various experiments were performed to assess the effects of EGCG on thickening of neointima, expression levels of high mobility group box 1 protein (HMGB1) and receptor of advanced glycation end products (RAGE), the inflammatory response, oxidative stress and activation of nuclear factor (NF)-κB. Results demonstrated that EGCG decreased the intimal area and the ratio of intimal area/medial area compared with the balloon injury group. The expression levels of HMGB1 and RAGE induced by balloon injury were markedly inhibited by EGCG treatment. Furthermore, the inflammatory response and oxidative stress damage, which have close correlations with HMGB1, were restrained by EGCG. Finally, EGCG treatment markedly inhibited NF-κB activation. The present data provided evidence that EGCG attenuates neointimal hyperplasia in a model of carotid artery balloon injury, which indicated that EGCG may serve as a potential drug for restenosis in clinics. |
| Databáze: | OpenAIRE |
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