A Cost-Benefit Comparison of Intensive Diabetes Management With Implantable Pumps Versus Multiple Subcutaneous Injections in Patients With Type I Diabetes
| Autor: | Brigitte Mace, Marie-Lou Ramaniche, Jean-Louis Selam, F. Bruzzo, Gérard Slama, M. J. Haardt, Catherine Dorange, Jean-Pierre Bethoux |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Blood Glucose Male Research design medicine.medical_specialty Time Factors Cost-Benefit Analysis Endocrinology Diabetes and Metabolism medicine.medical_treatment Diabetes management Diabetes mellitus Internal Medicine medicine Humans Insulin Prospective Studies Pancreatic hormone Advanced and Specialized Nursing Implantable Pump Analysis of Variance Chemotherapy Cross-Over Studies business.industry medicine.disease Crossover study Surgery Diabetes Mellitus Type 1 Anesthesia Injections Intravenous Costs and Cost Analysis Quality of Life Female France business |
| Zdroj: | Diabetes Care. 17:847-851 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE To investigate if intraperitoneal (IP) insulin infusion via programmable implantable pumps is a potential alternative to subcutaneous (SC) insulin via multiple injections. RESEARCH DESIGN AND METHODS We compared the cost-benefits of the two methods using a randomized, prospective, 6-month, crossover design in 10 adult type I diabetic patients. RESULTS When judged on the last month of IP versus SC periods in the nine patients who completed the study, metabolic data showed better glycemie control (HbA1c: 7.2 ± 0.2 IP vs. 8.5 ± 0.7% SC, mean ± SE, P = 0.02), reduced glycemie fluctuations (SD of capillary glucose values: 3.4 ± 0.2 IP vs. 4.6 ± 0.2 mM SC, P > 0.01), and fewer mild hypoglycemie events (5.7±2.0 IP vs. 10.0 ± 3.1 events/month SC, P = 0.02). Quality of life, judged by Diabetes Control and Complications Trial questionnaires, was unaffected by pump therapy. Direct costs, including pump acquisition, implantation, and follow-up, were 2.6-fold higher with IP than with SC delivery. CONCLUSIONS The implantable pump is more effective in the short term, equally accepted, but more costly than multiple injections and should be limited to patients with unsatisfactory glycemie control despite intensive diabetes management with SC insulin. In addition, longer-term, larger-scale, and comparative evaluation is required. |
| Databáze: | OpenAIRE |
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