AMH: An ovarian reserve biomarker in assisted reproduction
| Autor: | Carla Peluso, Bianca Bianco, Denise Maria Christofolini, Guilherme Gastaldo, Viviane Cavalcanti, Caio Parente Barbosa, Itatiana Rodart, Fernando Luiz Affonso Fonseca |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Anti-Mullerian Hormone
Infertility endocrine system medicine.medical_specialty Reproductive Techniques Assisted endocrine system diseases media_common.quotation_subject Clinical Biochemistry Controlled ovarian hyperstimulation Biochemistry Andrology Internal medicine Follicular phase medicine Humans Ovarian Reserve Ovarian reserve Ovulation Menstrual cycle media_common biology urogenital system Biochemistry (medical) Anti-Müllerian hormone General Medicine medicine.disease female genital diseases and pregnancy complications Endocrinology biology.protein Female Folliculogenesis Infertility Female Biomarkers |
| Zdroj: | Clinica Chimica Acta. 437:175-182 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2014.07.029 |
| Popis: | Ovarian reserve tests provide knowledge of a possible response to controlled ovarian hyperstimulation in patients undergoing assisted reproduction treatment, allowing management and alteration of treatment protocol with the appropriate dose of gonadotrophin. Several parameters have been used as predictors of ovarian response. The basal FSH serum level on the third day of the menstrual cycle seemed to be the best predictor, but with significant intraindividual variability from one cycle to another. Thus, the anti-Müllerian hormone (AMH) emerges as a new ovarian test marker. AMH is produced exclusively in the gonads, by the granulosa cells, and plays an important role in folliculogenesis, acting on the modulation of follicular recruitment in the granulosa cells in order to limit the number of recruited oocytes and to regulate the number of growing follicles and their selection for ovulation. It has been suggested that AMH is strongly associated with oocyte yield after ovarian stimulation and could therefore be capable of predicting the ovarian response and the quality of oocytes and embryos. In this review, we discuss the role of AMH in assisted reproduction outcomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect