SUPEROXIDE DISMUTASE ISOENZYMES, GLUTATHIONE PEROXIDASE AND SELENIUM IN BLOOD FROM HLA-B27-POSITIVE AND -NEGATIVE SUBJECTS
| Autor: | S. L. Marklund, H. Repo, S. Koskimies |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Antioxidant medicine.medical_treatment Immunology chemistry.chemical_element Biology Granulocyte Superoxide dismutase Selenium 03 medical and health sciences 0302 clinical medicine HLA Antigens Internal medicine HLA-DR4 Antigen Extracellular medicine Humans HLA-B27 Antigen 030304 developmental biology chemistry.chemical_classification Glutathione Peroxidase 0303 health sciences General Immunology and Microbiology Superoxide Dismutase Glutathione peroxidase HLA-DR Antigens General Medicine Isoenzymes Chemotaxis Leukocyte Red blood cell Enzyme medicine.anatomical_structure Endocrinology chemistry Biochemistry biology.protein Oxidation-Reduction 030215 immunology |
| Zdroj: | Acta Pathologica Microbiologica Scandinavica Series C: Immunology. :107-111 |
| ISSN: | 0108-0202 |
| DOI: | 10.1111/j.1699-0463.1987.tb00016.x |
| Popis: | We studied the activity of superoxide dismutase (SOD) isoenzymes (CuZnSOD, cyanide-resistant Mn-SOD and extracellular SOD), the concentration of plasma selenium (P-Se), and the activities of CuZn-SOD and glutathione peroxidase (GSHPx) in erythrocytes of 10 HLA-B27-positive and 10 HLA-B27-negative subjects whose sera had shown high and low chemokinetic activity, respectively, on migration of polymorphonuclear leukocytes (PMN) in vitro. No significant difference was found between the groups, suggesting that the enhanced chemokinetic activity of HLA-B27-positive sera does not derive from an aberration in serum anti-oxidant potentials. The results were also analysed on the basis of HLA-DR specificities: HLA-DR4-positive plasma samples had significantly lower levels of Se than HLA-DR4-negative ones. We therefore carried out a second series of experiments with sera of 37 subjects; the levels of P-Se in HLA-DR4-positive and -negative groups were much the same, as were the activities of GSHPx. The data suggest that there is no gross aberration in P-Se concentration in HLA-DR4-positive subjects. |
| Databáze: | OpenAIRE |
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