Alterations in Pulmonary Morphology and Peripheral Coagulation Profiles Caused by Intratracheal Inoculation of Live and Ultraviolet Light-killed Pasteurella haemolytica A1 in Calves
| Autor: | Trevor R. Ames, Douglas J. Weiss, Samuel K. Maheswaran, L. O. Whiteley |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Platelet Aggregation Ultraviolet Rays 040301 veterinary sciences Cattle Diseases Biology Fibrin Microbiology 0403 veterinary science Epithelial Damage 03 medical and health sciences Leukocytes medicine Ultraviolet light Animals Macrophage Pasteurellosis Pneumonic Blood Coagulation Lung Mannheimia haemolytica General Veterinary Inoculation Macrophages 04 agricultural and veterinary sciences biology.organism_classification Capillaries Pulmonary Alveoli Microscopy Electron 030104 developmental biology medicine.anatomical_structure Coagulation biology.protein Cattle Bacteria |
| Zdroj: | Veterinary Pathology. 28:275-285 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/030098589102800403 |
| Popis: | Eighteen male Holstein calves were divided into groups of three and inoculated intratracheally with 5 x 109 logarithmic phase or ultraviolet light-killed Pasteurella haemolytica biotype A serotype 1. Serial coagulation profiles were done on one calf from each group during the first 24 hours after inoculation. One calf from each group was necropsied at 4, 12, and 24 hours after inoculation and lesions were characterized with light and transmission electron microscopy. We found that 1) the pulmonary intravascular macrophage may have an important role in the early intravascular inflammatory events; 2) there was morphologic evidence for local initation of the coagulation cascade in the lung early in the disease process but it was not a consumptive process; and 3) killed-bacteria were capable of causing fibrin exudation, platelet aggregation and alveolar epithelial damage similar to live bacteria, but the degenerative changes in neutrophils, endothelial cells and intravascular fibrin formation that occur with live bacteria were not seen. |
| Databáze: | OpenAIRE |
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