Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy
| Autor: | Andrea Porcheddu, Ivan Halasz, Evelina Colacino, Anita Dogan, Fabien Caron, Ernest Meštrović, Irena Sović, Thomas Perilli, Francesco Delogu, Pier Carlo Ricci, Stipe Lukin |
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| Přispěvatelé: | Rudjer Boskovic Institute [Zagreb], Dipartimento di Scienze Chimiche e Geologiche Centro Grandi Strumenti and INSTM unit, Università di Cagliari, Dipartimento di Ingegneria Meccanica, Universita degli Studi di Cagliari [Cagliari], Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Active ingredient
010405 organic chemistry Chemistry General Chemical Engineering Pharmacy General Chemistry 010402 general chemistry Silver sulfadiazine 01 natural sciences Ammonia Raman spectroscopy Chemical reactions Pharmaceuticals : Silver 0104 chemical sciences In situ raman spectroscopy medicine [CHIM]Chemical Sciences QD1-999 Nuclear chemistry medicine.drug |
| Zdroj: | ACS Omega ACS Omega, ACS Publications, 2020, 5 (44), pp.28663-28672. ⟨10.1021/acsomega.0c03756⟩ ACS Omega, Vol 5, Iss 44, Pp 28663-28672 (2020) |
| ISSN: | 2470-1343 |
| Popis: | International audience; The mechanochemical preparation of silver sulfadiazine and dantrolene, two marketed active pharmaceutical ingredients, was investigated by in situ Raman spectroscopy. For the first time, the mechanochemical transformations involving highly fluorescent compounds could be studied in situ with a high-resolution Raman system combined with a unique suitable Raman probe. Moreover, the kinetic features of the mechanochemical process were examined by a mathematical model allowing to describe the chemical changes under mechanical stress. This approach is promising both to broaden the scope of Raman in situ investigations that would otherwise be impossible and for process optimization at any scale. |
| Databáze: | OpenAIRE |
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