EFFECT OF THYROTROPHIN RELEASING HORMONE (TRH) IN PATIENTS WITH PITUITARY DISORDERS
| Autor: | Lotte Hummer, Jörgen Lindholm, H. Dige-Petersen, Peter A. Rasmussen, O. Korsgaard |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Hypophysectomy Pituitary disorder endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyrotropin Chromophobe cell Thyroxine-Binding Proteins Endocrinology TRH stimulation test Thyroid-stimulating hormone Internal medicine medicine Humans Pituitary Neoplasms Euthyroid Thyrotropin-Releasing Hormone Adenoma Chromophobe Triiodothyronine business.industry General Medicine Middle Aged Thyroxine Acromegaly Female Thyroid function business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Acta Endocrinologica. 85:479-487 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0850479 |
| Popis: | The secretion and biological activity of thyroid stimulating hormone (TSH) were studied in 22 patients with a pituitary tumour (17 acromegalics and 5 patients with a chromophobe adenoma) and in 36 hypophysectomized patients (16 acromegalics and 20 with a chromophobe adenoma). Thyroid function was assessed by serum thyroxine (T4), serum triiodothyronine (T3), and thyroxine-binding globulin (TBG) concentration. Serum TSH was measured before and after injection of TSH releasing hormone (TRH), and in 19 hypophysectomized patients the T3 response after TRH was measured. In addition a TRH test was performed 1–2 weeks after surgery in 11 patients. The basal serum TSH did not differ from euthyroid control values in any of the groups and no late effect of hypophysectomy was observed. Subnormal peak TSH values were seen in 10 out of 37 euthyroid patients, whereas 9 out of 11 hypothyroid patients responded normally. Hypophysectomy caused an immediate but transient decrease in peak TSH in patients with a chromophobe adenoma only. The rise in serum T3 after TRH was significantly lower in hypophysectomized patients than in controls. An increase in TSH was followed by a T3 response in all patients except in 4 out of 8 euthyroid acromegalics. In patients operated on for a chromophobe adenoma the T3 response was correlated with serum T4, whereas this was not the case in acromegalics. |
| Databáze: | OpenAIRE |
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