Gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties
| Autor: | Pranav Soman, Yong X. Chen, B P Cain |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
food.ingredient Composite number macromolecular substances 02 engineering and technology Matrix (biology) 010402 general chemistry 01 natural sciences Gelatin Viscoelasticity gelatin Extracellular matrix food lcsh:TA401-492 alginate Composite material technology industry and agriculture viscoelastic properties 021001 nanoscience & nanotechnology Gelatin methacrylate 0104 chemical sciences elastic recovery Creep Self-healing hydrogels lcsh:Materials of engineering and construction. Mechanics of materials hydrogel 0210 nano-technology |
| Zdroj: | AIMS Materials Science, Vol 4, Iss 2, Pp 363-369 (2017) |
| ISSN: | 2372-0484 |
| DOI: | 10.3934/matersci.2017.2.363 |
| Popis: | Although native extracellular matrix (ECM) is viscoelastic, synthetic biomaterials used in biomedical engineering to mimic ECM typically exhibit a purely elastic response when an external strain is applied. In an effort to truly understand how living cells interact with surrounding ECM matrix, new biomaterials with tunable viscoelastic properties continue to be developed. Here we report the synthesis and mechanical characterization of a gelatin methacrylate-alginate (Gel-Alg) composite hydrogel. Results obtained from creep and compressive tests reveal that the alginate component of Gel-Alg composite, can be effectively crosslinked, un-crosslinked and re-crosslinked by adding or chelating Ca2+ ions. This work demonstrates that Gel-Alg is capable of tuning its viscoelastic strain and elastic recovery properties, and can be potentially used to design ECM-mimicking hydrogels. |
| Databáze: | OpenAIRE |
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