Restoring VTA DA neurons excitability accelerates emergence from sevoflurane general anesthesia of anxiety state
Autor: | Xin Wang, Wang Xiaoli, Ji Hu, Hong-Miao Cai, Huoqing Luo, Juan-Guo, Xiao-Hui Sun, Peilin Cong, Le Yu, Yuan-Jun Qin, Na Sun, Ming Xue, Qingxiu Wang, Zhao Li, Hui Wang, Ai-Lian Zhang, Ming Chen |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Biophysics Stimulation Optogenetics Anxiety Biochemistry Sevoflurane Anxiety state 03 medical and health sciences Mice 0302 clinical medicine mental disorders medicine Animals Molecular Biology business.industry Dopaminergic Neurons Ventral Tegmental Area Cell Biology Mice Inbred C57BL 030104 developmental biology nervous system 030220 oncology & carcinogenesis Anesthesia Anesthetics Inhalation Female medicine.symptom business psychological phenomena and processes medicine.drug |
Zdroj: | Biochemical and biophysical research communications. 565 |
ISSN: | 1090-2104 |
Popis: | Preoperative anxiety is common and often comes with a higher probability of worse recovery. However, the neurological mechanism of the effect of preoperative anxiety on general anesthesia and subsequent awakening remains unknown. In this study, we report an anxious state results in delayed awakening in anxiety model mice from sevoflurane general anesthesia. More profound inhibition of DA neurons in the VTA contributes to delayed awakening. Optogenetic stimulation of VTA DA neurons can reverse the delay. The results indicate that VTA DA neurons may be involved in the delay in awakening from general anesthesia caused by anxiety. |
Databáze: | OpenAIRE |
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