Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis
| Autor: | Bernard M. J. Uitdehaag, Timo K. van den Berg, Rianka P. M. Vloet, Roeland Hanemaaijer, Charlotte E. Teunissen, Holger Jon Møller, Babs O. Fabriek, Christine D. Dijkstra, Lisa van Winsen |
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| Přispěvatelé: | Molecular cell biology and Immunology, Neurology, Amsterdam institute for Infection and Immunity, General Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Adolescent Hydrocortisone medicine.medical_treatment Immunology Antigens Differentiation Myelomonocytic Enzyme-Linked Immunosorbent Assay Receptors Cell Surface Biology Protein degradation Matrix metalloproteinase Transfection Statistics Nonparametric Proinflammatory cytokine Cricetulus Downregulation and upregulation Antigens CD Internal medicine Cricetinae medicine Immunology and Allergy Animals Humans Scavenger receptor Enzyme Inhibitors Aged Cell Line Transformed Aged 80 and over Multiple sclerosis Middle Aged medicine.disease Endocrinology Cytokine Neurology Matrix Metalloproteinase 9 Cytokines Matrix Metalloproteinase 2 Female Neurology (clinical) CD163 |
| Zdroj: | Journal of Neuroimmunology, 187(1-2), 179-86. Elsevier Journal of neuroimmunology, 187(1-2), 179-186. Elsevier Fabriek, B O, Møller, H J, Vloet, R P M, van Winsen, L M, Hanemaaijer, R, Teunissen, C E, Uitdehaag, B M J, van den Berg, T K & Dijkstra, C D 2007, ' Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis. ', Journal of Neuroimmunology, vol. 187, no. 1-2, pp. 179-86 . https://doi.org/10.1016/j.jneuroim.2007.04.016 Fabriek, B O, Møller, H J, Vloet, R P M, van Winsen, L M, Hanemaaijer, R, Teunissen, C E, Uitdehaag, B M J, van den Berg, T K & Dijkstra, C D 2007, ' Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis ', Journal of Neuroimmunology, vol. 187, no. 1-2, pp. 179-86 . https://doi.org/10.1016/j.jneuroim.2007.04.016 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2007.04.016 |
| Popis: | The scavenger receptor CD163 is selectively expressed on tissue macrophages and human monocytes. CD163 has been implicated to play a role in the clearance of hemoglobin and in the regulation of cytokine production by macrophages. Membrane CD163 can be cleaved by matrix metalloproteinases (MMP) resulting in soluble CD163 (sCD163). In the present report the shedding of CD163 was investigated in multiple sclerosis (MS). An upregulation of plasma sCD163 and a down regulation of membrane CD163 in MS patients compared to healthy controls was observed. The levels of plasma sCD163 correlated with plasma MMP-9 levels in controls, but not in MS patients. Moreover, evidence was obtained for CD163-cleaving MMP activity in plasma of MS patients. Finally, the increased proteolytic shedding of CD163 correlated to reduced plasma levels of circulating inflammatory cytokines. Collectively, our results provide evidence for proteolytic shedding of CD163 in MS and suggest a possible link to cytokine production. © 2007 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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