Subsensitivity of T lymphocytes to sympathomimetic and cholinergic stimulation in bronchial asthma
| Autor: | Michael H. Grieco, Zarina Goel, Paul Lang |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male medicine.medical_specialty Rosette Formation Adrenergic receptor T-Lymphocytes Immunology Adrenergic Stimulation Pathogenesis Theophylline Internal medicine medicine Immunology and Allergy Humans Sympathomimetics Phenylephrine Asthma Alpha adrenergic agent business.industry Isoproterenol Middle Aged medicine.disease Endocrinology Parasympathomimetics Cholinergic Carbachol Female business medicine.drug |
| Zdroj: | The Journal of allergy and clinical immunology. 61(4) |
| ISSN: | 0091-6749 |
| Popis: | The effect of adrenergic and cholinergic drugs on short incubation "active" E rosette formation was studied in 19 patients with bronchial asthma and 17 healthy controls. Both groups had an equal absolute number of baseline "active" E rosettes, but the asthmatics demonstrated a higher percent baseline value. The beta adrenergic drug isoproterenol (10 −3 M) inhibited the formation of "active" E rosettes in asthmatics by only 18.0% as compared to a 60.8% inhibition in the control group. Carbamylcholine (10 −5 M) a cholinergic agonist, also showed a lower than normal response in asthmatics, 34.3% enhancement of "active" E rosetting compared to a 52.4% enhancement in the controls. The alpha adrenergic agent phenylephrine (10 −5 M) exhibited equal enhancing effects in both groups, 34.2% in the asthmatics and 36.5% in the controls. Isoproterenol (10 −3 M) had a minimal effect on inhibition of long incubation "total" E rosettes in both groups studied. The beta adrenergic abnormality conforms to the beta blockade theory of asthma of Szentivanyi. The cholinergic abnormality is unexplained in view of the hyperresponsiveness of patients with asthma to cholinergic agents in vivo. Patients with bronchial asthma probably have an autonomic dysfunction that may play a role in the pathogenesis of their disease. |
| Databáze: | OpenAIRE |
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