An implicit and reliable neural measure quantifying impaired visual coding of facial expression: evidence from the 22q11.2 deletion syndrome
| Autor: | Hugo Fumat, Caroline Demily, Alexandre Yailian, Nicolas Franck, Juliette Klamm, Emilie Favre, Isabelle Amado, Jean-Yves Baudouin, Arnaud Leleu |
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| Přispěvatelé: | Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Développement, Individu, Processus, Handicap, Éducation (DIPHE), Université Lumière - Lyon 2 (UL2), Institut des Sciences Cognitives (ISC), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Leleu, Arnaud, Demily, Caroline, Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier le Vinatier [Bron], Université Montpellier 1 (UM1), Université Paris Descartes - Paris 5 (UPD5), 'Le Vinatier' Psychiatric hospital (CSR grant), the 'Conseil Régional Bourgogne Franche-Comté' (PARI grant to J.-Y.B. and A.L.), the FEDER (European Funding for Regional Economic Development), and the French 'Investissements d’Avenir' program, project ISITE-BFC (contract ANR-15-IDEX-03 to J.-Y.B. and A.L.). |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Brain activity and meditation Emotions Audiology Electroencephalography [SCCO]Cognitive science 0302 clinical medicine ComputingMilieux_MISCELLANEOUS Cerebral Cortex education.field_of_study medicine.diagnostic_test Facial Expression Psychiatry and Mental health Social Perception Female Neurosciences (Sciences cognitives) Facial Recognition Adult medicine.medical_specialty Psychosis Adolescent Population Article lcsh:RC321-571 Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience DiGeorge Syndrome medicine Humans Cognitive Dysfunction education lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Facial expression business.industry [SCCO.NEUR]Cognitive science/Neuroscience medicine.disease 030104 developmental biology [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health Endophenotype Psychiatrics and mental health business Psychiatrie et santé mentale Neurocognitive 030217 neurology & neurosurgery Neuroscience Coding (social sciences) |
| Zdroj: | Translational Psychiatry Translational Psychiatry, Nature Pub. Group, 2019, 9 (1) Translational Psychiatry, Vol 9, Iss 1, Pp 1-11 (2019) Translational Psychiatry 1 (9), 67. (2019) Translational Psychiatry, Nature Pub. Group, 2019, 9 (1), pp.67. ⟨10.1038/s41398-019-0411-z⟩ |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-019-0411-z⟩ |
| Popis: | Although various psychiatric disorders present with social-cognitive impairment, a measure assessing social-cognitive processes implicitly and reliably, with high selectivity and with enough signal-to-noise ratio (SNR) for individual evaluation of any population at any age, is lacking. Here we isolate a neural marker quantifying impaired visual coding of facial expression in individuals with 22q11.2 deletion syndrome (22q11DS) using frequency-tagging with electroencephalography (EEG). Twenty-two 22q11DS participants and 22 healthy controls were presented with changes of facial expression displayed at low, moderate, and high intensities every five cycles in a stream of one neutral face repeating 6 times per second (i.e., at a 6 Hz base rate). The brain response to expression changes tagged at the 1.2 Hz (i.e., 6 Hz/5) predefined frequency was isolated over occipito-temporal regions in both groups of participants for moderate- and high-intensity facial expressions. Neural sensitivity to facial expression was reduced by about 36% in 22q11DS, revealing impaired visual coding of emotional facial signals. The significance of the expression-change response was estimated for each single participant thanks to the high SNR of the approach. Further analyses revealed the high reliability of the response and its immunity from other neurocognitive skills. Interestingly, response magnitude was associated with the severity of positive symptoms, pointing to a potential endophenotype for psychosis risk. Overall, the present study reveals an objective, selective, reliable, and behavior-free signature of impaired visual coding of facial expression implicitly quantified from brain activity with high SNR. This novel tool opens avenues for clinical practice, providing a potential early biomarker for later psychosis onset and offering an alternative for individual assessment of social-cognitive functioning in even difficult-to-test participants. |
| Databáze: | OpenAIRE |
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