Erythrocyte survival following thermal injury
| Autor: | P.William Curreri, Edward C. Loebl, Charles R. Baxter, Janet A. Marvin |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
Anemia Hemolytic Time Factors Cell Survival Spleen Andrology Erythrocyte survival Blood Transfusion Autologous medicine Distribution (pharmacology) Humans Blood Transfusion Aspirin Red Cell Thermal injury business.industry Heparin Erythrocyte Aging Crossover study Chromium Radioisotopes Surgery medicine.anatomical_structure Liver business Burns medicine.drug Half-Life |
| Zdroj: | The Journal of surgical research. 16(2) |
| ISSN: | 0022-4804 |
| Popis: | A three-part study of erythrocyte survival was carried out in burned patients to clarify the mechanisms responsible for the rapid disappearance of red cell mass during the first week following major thermal injury. Tagged erythrocytes from burned patients and nonburned volunteers were utilized in a crossover study of red cell survival. The half-life of normal erythrocytes from non-burned donors was markedly decreased when administered to burned patients ( t 1 2 = 6.3 ± 1.1 days ). The autologous half-life of the burned patients own erythrocytes was similarly decreased ( t 1 2 = 8.5 ± 1.5 days ). However, when the burned patients' cells were studied in non-burned volunteers, red cell survival was found to be normal ( t 1 2 = 23.3 ± 1.8 days ). External counting of the distribution of radioisotope following injection of 51Cr labeled erythrocytes failed to demonstrate progressive accumulation in the burn wound or the spleen, implying that these areas are not the primary sites of red cell removal from the circulation. A randomized program of treatment with aspirin or low-dose heparin in a small series of burned patients was conducted to determine effects of such therapy on autologous erythrocyte survival. The half-life of erythrocytes in heparin-treated patients (7.7 ± 1.4 days) and aspirin-treated patients (6.7 ± 1.0 days) were not significantly different from the survival of autologous erythrocytes in burn patients not receiving these drugs (8.5 ± 1.5 days). This study characterized, but did not precisely identify, a humoral mechanism which results in increased erythrocyte destruction following thermal injury. |
| Databáze: | OpenAIRE |
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