Pituitary Cushing's syndrome and Nelson's syndrome: diagnostic criteria, surgical therapy, and results
| Autor: | William D. Kerr, Frank W. Guthrie, Ivan Ciric, E.Dennis Murphy, Steven Hayashida |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypophysectomy endocrine system diseases Hydrocortisone medicine.medical_treatment Adrenocorticotropic hormone Pituitary neoplasm Dexamethasone Nelson Syndrome Diagnosis Differential Cushing syndrome Adrenocorticotropic Hormone medicine Humans Pituitary Neoplasms Cushing Syndrome business.industry Nelson's syndrome Middle Aged medicine.disease Surgery Diabetes insipidus Female Neurology (clinical) business medicine.drug |
| Zdroj: | Surgical neurology. 16(5) |
| ISSN: | 0090-3019 |
| Popis: | Eight patients with pituitary Cushing's syndrome and 2 with Nelson's syndrome were followed from one to ten years after removal of pituitary adenomas. A detailed assessment of the pituitary-adrenal axis was obtained in all patients when last seen, save the first, who had undergone a complete hypophysectomy ten years previously. Long-term observations have shown sustained endocrine cure in 7 of 8 patients with pituitary Cushing's syndrome. One patient with Nelson's syndrome was also cured. There was no operative morbidity or mortality. There were no instances of diabetes insipidus. The long-term results in this study indicate that patients with pituitary Cushing's syndrome have a better than 90% chance of being cured after transsphenoidal removal of the pituitary (micro) adenomas. Current diagnostic and therapeutic concepts in the management of pituitary Cushing's syndrome are discussed in detail. |
| Databáze: | OpenAIRE |
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