Role of cytokines in healing chronic skin wounds
| Autor: | Charlotte Nath, Subhash C. Gulati |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Chronic wound
Cell type Skin wound Ischemia Inflammation Stimulation Skin Diseases medicine Animals Humans Growth Substances Wound Healing business.industry Single factor Hematology General Medicine medicine.disease Diabetic Foot Immunology Chronic Disease Costs and Cost Analysis Cytokines medicine.symptom Wound healing business |
| Zdroj: | Acta haematologica. 99(3) |
| ISSN: | 0001-5792 |
| Popis: | In the chronic wound, the normal cascade of inflammation, granulation and reconstruction phases of healing is interrupted. Cytokines are now known to orchestrate different biochemical mediators resulting in the restoration of the healing phases. Growth factors may play a significant role in stimulating wound repair by stimulating growth and proliferation. Since growth factors stimulate a variety of functions depending on cell type and wound stage and since wound-healing defects may occur at any phase of healing, a mixed combination of growth factors would be predicted to be more effective than a single factor. Factors that may modulate the action of growth factors include electrical stimulation, weight bearing, debriding and ischemia. |
| Databáze: | OpenAIRE |
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