Efavirenz intoxication due to slow hepatic metabolism

Autor:	M. Krause, Gabriela Bleiber, Barbara Hasse, Huldrych F. Günthard
Jazyk:	angličtina
Rok vydání:	2005
Předmět:	Adult Cyclopropanes Microbiology (medical) Psychosis Efavirenz CYP2B6 Anti-HIV Agents Human immunodeficiency virus (HIV) HIV Infections Pharmacology medicine.disease_cause Psychoses Substance-Induced chemistry.chemical_compound immune system diseases Oxazines parasitic diseases medicine Humans Genetic Predisposition to Disease heterocyclic compounds Allele Alleles Dose-Response Relationship Drug business.industry Homozygote Anti-HIV Agents/adverse effects Anti-HIV Agents/blood Anti-HIV Agents/metabolism Aryl Hydrocarbon Hydroxylases/genetics HIV Infections/drug therapy Liver/enzymology Oxazines/adverse effects Oxazines/blood Oxazines/metabolism Oxidoreductases N-Demethylating/genetics Psychoses Substance-Induced/diagnosis virus diseases Oxidoreductases N-Demethylating biochemical phenomena metabolism and nutrition Hiv seropositivity medicine.disease Benzoxazines Cytochrome P-450 CYP2B6 Infectious Diseases Liver metabolism Liver chemistry Alkynes Immunology Female Aryl Hydrocarbon Hydroxylases business Drug metabolism
Zdroj:	Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, vol. 40, no. 3, pp. e22-e23
Popis:	We describe a human immunodeficiency virus-positive woman who presented with severe psychosis while she was receiving therapy with efavirenz. Her plasma efavirenz level was excessively high. Genetic investigation showed that she was homozygous for the CYP2B6 G516T allele, resulting in slow hepatic metabolism. After the dosage of efavirenz was lowered, all neuropsychiatric symptoms subsided.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75eb3a8b2f83a7fdacfb6f4647260507 https://serval.unil.ch/notice/serval:BIB_94D5173C4402 Zobrazit plný text záznamu