Nanoskin® Subcutaneous Implant in Guinea Pigs
| Autor: | Kryscia Leiko Natsuaki Kaminagakura, Pierre Basmaji, Carlos Roberto Padovani, Patricia Sugino, Laryssa Kataki, Silvana Artioli Schellini, Daniela Carvalho dos Santos, Silvana Sue Sato |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty food.ingredient Guinea Pigs Tissue integration Mild inflammation Biocompatible Materials Gelatin 03 medical and health sciences 0302 clinical medicine food Medicine Animals Cellulose business.industry Biomaterial Eyelids 030208 emergency & critical care medicine Subcutaneous implant General Medicine Prostheses and Implants Biocompatible material Nanostructures Ophthalmology Disease Models Animal medicine.anatomical_structure Dorsal region 030221 ophthalmology & optometry Surgery Eyelid business |
| Zdroj: | Ophthalmic plastic and reconstructive surgery. 34(2) |
| ISSN: | 1537-2677 |
| Popis: | PURPOSE To evaluate the suitability of Nanoskin, a biomaterial derived from bacterial cellulose, as an alternate material for repairing the posterior lamellae of the eyelids. METHODS Forty guinea pigs received a fragment of Nanoskin subcutaneously in the dorsal region. The animals received Nanoskin (group 1) or Nanoskin coated with a gelatin layer (group 2). The animals were observed daily for over 7, 30, 90, or 180 days with the subcutaneous implants in place. The animals were euthanized at a designated time and the Nanoskin was removed for histologic, morphometric, and transmission electron microscopy evaluation. RESULTS The results were similar for both groups. The subcutaneously implanted Nanoskin resulted in good tissue integration, induced mild inflammation, and was surrounded by a delicate pseudocapsule. CONCLUSION The good tissue integration of Nanoskin in study indicates that it may be a potential material for application as a substitute of posterior eyelid lamellar tissue. Further clinical studies are required to confirm the preliminary outcomes of this experimental study. |
| Databáze: | OpenAIRE |
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