Lithiation of Functionalized Fluoroquinolines: Synthesis of Dihalo-2-phenylquinoline-4-carboxamides and in Vitro Evaluation as NK-3 Receptor Ligands for Medical Imaging Studies

Autor:	Louisa Barré, Sylvie Tymciu, Cécile Perrio, Florence Mongin, Marie‐Claire Lasne, Idriss Bennacef, Martine Dhilly, Guy Quéguiner
Rok vydání:	2004
Předmět:	Hydrocarbons Fluorinated medicine.drug_class Stereochemistry Metalation chemistry.chemical_element Carboxamide Lithium Single-photon emission computed tomography Ligands Ring (chemistry) Chemical synthesis Catalysis Radioligand Assay chemistry.chemical_compound medicine Tomography Emission-Computed Single-Photon Molecular Structure medicine.diagnostic_test Ligand Organic Chemistry Quinoline Halogenation Receptors Neurokinin-3 General Medicine Combinatorial chemistry In vitro chemistry Positron emission tomography Quinolines Fluorine Indicators and Reagents Tomography Emission-Computed
Zdroj:	The Journal of Organic Chemistry. 69:2622-2625
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo0358426
Popis:	Fluoroiodo-2-phenylquinoline-4-carboxamides, analogues of NK-3 antagonist SB 223412, were synthesized and evaluated as NK-3 ligands with the aim of developing radioligands suitable for both Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) studies. The key step utilizes metalation directed by the fluorine atom for iodination of the quinoline ring.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e9babd34fde58aa85a1c6b6ecb5c4a https://doi.org/10.1021/jo0358426 Zobrazit plný text záznamu