Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease
| Autor: | Jorge Kalil, Sandrine Cabantous, Pablo Maria Alberto Pomerantzeff, Christophe Chevillard, Ronaldo Honorato Barros Santos, Isabela Cunha Navarro, Monique Andrade Baron, Priscila Camillo Teixeira, Ludmila Rodrigues Pinto Ferreira, Luiz Alberto Benvenuti, Fernando Bacal, Laurie Laugier, Amanda Farage Frade, Fábio Antônio Gaiotto, Darlan da Silva Cândido, Frederico Moraes Ferreira, Edecio Cunha-Neto |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Chagas disease Male Pathology medicine.medical_specialty Cardiomyopathy Myocardial Infarction 030204 cardiovascular system & hematology 03 medical and health sciences Mice 0302 clinical medicine Gene expression medicine Immunology and Allergy Animals Humans Chagas Disease Myocardial infarction Epigenetics business.industry Gene Expression Profiling Dilated cardiomyopathy medicine.disease Long non-coding RNA 3. Good health 030104 developmental biology Infectious Diseases Biomarker (medicine) Female RNA Long Noncoding business Transcription Factors |
| Zdroj: | The Journal of infectious diseases. 214(1) |
| ISSN: | 1537-6613 |
| Popis: | Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC. |
| Databáze: | OpenAIRE |
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