New zebrafish model for monitoring proximal tubule physiology in genetic and acquired renal Fanconi syndromes
| Autor: | Rebecca A. Wingert, Joseph M. Chambers |
|---|---|
| Přispěvatelé: | University of Zurich, Wingert, Rebecca A |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nephrology medicine.medical_specialty 030232 urology & nephrology Kidney Endocytosis Pronephros Kidney Tubules Proximal 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Vitamin D and neurology Animals Humans Zebrafish 2727 Nephrology Proteinuria biology Fanconi Syndrome biology.organism_classification 10124 Institute of Molecular Life Sciences Cell biology 030104 developmental biology medicine.anatomical_structure 570 Life sciences Proximal tubule medicine.symptom Function (biology) |
| Zdroj: | Kidney International. 97:1097-1099 |
| ISSN: | 0085-2538 |
| DOI: | 10.1016/j.kint.2020.02.014 |
| Popis: | Inherited and acquired disorders that affect proximal tubule endocytosis and lysosomal processing manifest with improper loss of solutes and proteins. The zebrafish pronephros is conserved with humans and is used to model numerous renal conditions, but has few quantitative measures for proximal tubule function. Here, Chen et al. developed a high-throughput assay to quantify proteinuria and lysosomal processing in transgenic zebrafish by labeling vitamin D protein, allowing for precise reporting of proximal tubule function. |
| Databáze: | OpenAIRE |
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