Is the Post-Radical Prostatectomy Gleason Score a Valid Predictor of Mortality after Neoadjuvant Hormonal Treatment?

Autor: Manfred P. Wirth, Gustavo Baretton, Angelika Borkowetz, Michael Froehner, Stefan Propping, Marieta Toma, Dorothea Liebeheim, Rainer Koch
Rok vydání: 2015
Předmět:
Male
Oncology
medicine.medical_specialty
Antineoplastic Agents
Hormonal
Urology
medicine.medical_treatment
030232 urology & nephrology
Prostatakrebs
Radikale Prostatektomie
Prognostische Faktoren
Hormonale Behandlung
Neoadjuvant
Gleason-Score
Forschung zu Gesundheitsergebnissen
urologic and male genital diseases
Prostate cancer
Radical prostatectomy
Prognostic factors
Hormonal treatment
Neoadjuvant
Gleason score
Health outcomes research
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Internal medicine
Humans
Medicine
ddc:610
neoplasms
Aged
Proportional Hazards Models
Prostatectomy
Gynecology
business.industry
Prostate
Prostatic Neoplasms
Reproducibility of Results
Middle Aged
medicine.disease
Neoadjuvant Therapy
Treatment Outcome
030220 oncology & carcinogenesis
Neoplasm Grading
business
Follow-Up Studies
Zdroj: Urologia Internationalis. 96:302-308
ISSN: 1423-0399
0042-1138
Popis: Purpose: To evaluate the validity of the Gleason score after neoadjuvant hormonal treatment as predictor of disease-specific mortality after radical prostatectomy. Patients and Methods: A total of 2,880 patients with a complete data set and a mean follow-up of 10.3 years were studied; 425 of them (15%) had a history of hormonal treatment prior to surgery. The cumulative incidence of deaths from prostate cancer was determined by univariate and multivariate competing risk analysis. Cox proportional hazard models for competing risks were used to study combined effects of the variables on prostate cancer-specific mortality. Results: A higher portion of specimens with a history of neoadjuvant hormonal treatment were assigned Gleason scores of 8-10 (28 vs. 17%, p < 0.0001). The mortality curves in the Gleason score strata Conclusion: This study suggests that the prognostic value of the post-radical prostatectomy Gleason score is not meaningfully jeopardized by heterogeneous neoadjuvant hormonal treatment in a routine clinical setting.
Databáze: OpenAIRE
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