Synthesis, Molecular Modeling and Biological Evaluation of 4-Alkoxyquinazoline Derivatives as Novel Inhibitors of VEGFR2
| Autor: | Liang Lu, Ting-Ting Zhao, Chen Xu, Tian-Bao Liu, Wen-Xue Sun, Dong-Dong Li, Hai-Liang Zhu |
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| Rok vydání: | 2016 |
| Předmět: |
Models
Molecular 0301 basic medicine Antineoplastic Agents Pharmacology HeLa Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Line Tumor Drug Discovery Quinazoline Humans Structure–activity relationship Protein Kinase Inhibitors IC50 Cell Proliferation Dose-Response Relationship Drug Molecular Structure biology Active site Kinase insert domain receptor General Chemistry General Medicine biology.organism_classification Vascular Endothelial Growth Factor Receptor-2 030104 developmental biology chemistry Biochemistry Docking (molecular) Cell culture 030220 oncology & carcinogenesis Quinazolines biology.protein Drug Screening Assays Antitumor |
| Zdroj: | CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1570-1575 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.c16-00386 |
| Popis: | A series of novel quinazoline derivatives have been designed and synthesized, and their inhibitory activities have also been tested against A549 (carcinomic human alveolar basal epithelial cell), MCF-7 (breast cancer) and HeLa (cervical cancer cell). Of these compounds, compound 4t showed the most potent inhibitory activity (IC50=0.22 µg/mL for HeLa, IC50=0.15 µg/mL for A549 and IC50=0.24 µg/mL for MCF-7). Docking simulation had been performed to position compound 4t into the vascular endothelial growth factor receptor (VEGFR) active site to determine the probable binding model. These results suggested that compound 4t with potent inhibitory activity in tumor growth inhibition may be a potential anticancer agent. |
| Databáze: | OpenAIRE |
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