Programmable assembly of nanoarchitectures using genetically engineered viruses
| Autor: | Yan Gao, Yu Huang, E. L. Hu, Soo Kwan Lee, Angela M. Belcher, James J. De Yoreo, Chung-Yi Chiang |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Nanostructure
Materials science viruses Nanowire Molecular Conformation Nanoparticle Bioengineering Nanotechnology Viral Proteins Molecular recognition Materials Testing General Materials Science Particle Size M13 bacteriophage biology Mechanical Engineering General Chemistry Condensed Matter Physics biology.organism_classification Nanostructures Template Capsid Self-assembly Crystallization Genetic Engineering Bacteriophage M13 |
| Zdroj: | Nano letters. 5(7) |
| ISSN: | 1530-6984 |
| Popis: | Biological systems possess inherent molecular recognition and self-assembly capabilities and are attractive templates for constructing complex material structures with molecular precision. Here we report the assembly of various nanoachitectures including nanoparticle arrays, hetero-nanoparticle architectures, and nanowires utilizing highly engineered M13 bacteriophage as templates. The genome of M13 phage can be rationally engineered to produce viral particles with distinct substrate-specific peptides expressed on the filamentous capsid and the ends, providing a generic template for programmable assembly of complex nanostructures. Phage clones with gold-binding motifs on the capsid and streptavidin-binding motifs at one end are created and used to assemble Au and CdSe nanocrytals into ordered one-dimensional arrays and more complex geometries. Initial studies show such nanoparticle arrays can further function as templates to nucleate highly conductive nanowires that are important for addressing/interconnecting individual nanostructures. |
| Databáze: | OpenAIRE |
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