MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3

Autor:	Jin Li, Zi-Hui Wang, Ya-Min Dang, Dan-Ni Li, Zhen Liu, Da-Peng Dai, Jian-Ping Cai
Rok vydání:	2022
Předmět:	STAT3 Transcription Factor Transcriptional Activation DNA Repair Enzymes Physiology (medical) MCF-7 Cells Neoplastic Stem Cells Humans Breast Neoplasms Female Biochemistry Phosphoric Monoester Hydrolases Up-Regulation
Zdroj:	Free Radical Biology and Medicine. 188:447-458
ISSN:	0891-5849
Popis:	MTH1 protein can sanitize the damaged (d)NTP pool and MTH1 inhibitors have been developed to impede the growth of rapidly proliferating tumor cells; however, the effect of MTH1 inhibition on breast cancer stemness has not been reported yet. Here, we constructed breast cancer cell lines with the stable depletion of MTH1. MTH1 suppression clearly increased the ratio of CD44
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dfde2107b01d2a35dd1fbb4051da32 https://doi.org/10.1016/j.freeradbiomed.2022.06.240 Zobrazit plný text záznamu Full Text from ScienceDirect