Azathioprine plus prednisone in treatment of pemphigoid
| Autor: | R R Harman, R.D.G. Peachey, R P Warin, J L Burton |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Pemphigoid medicine.medical_specialty Azathioprine Pharmacology Gastroenterology law.invention Pharmacotherapy Randomized controlled trial law Prednisone Internal medicine Medicine Humans General Environmental Science Aged Clinical Trials as Topic Skin Diseases Vesiculobullous business.industry Maintenance dose Standard treatment General Engineering General Medicine medicine.disease Clinical trial General Earth and Planetary Sciences Drug Therapy Combination Female business medicine.drug Follow-Up Studies Research Article |
| Zdroj: | British medical journal. 2(6146) |
| ISSN: | 0007-1447 |
| Popis: | Twenty-five patients taking part in a controlled trial to compare azathioprine plus prednisone with prednisone alone in the treatment of pemphigoid were followed up for three years. Results showed that the addition of azathioprine 2.5 mg/kg body weight daily reduced the total maintenance dose of prednisone needed by about 45%, with no increase in serious side effects or mortality. The suggestion that azathioprine might increase the risk of disseminated malignancy in elderly patients was not supported. We conclude that in future trials the combination of azathioprine with prednisone should be used as the standard treatment for comparison. |
| Databáze: | OpenAIRE |
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