The application of comet assay in monitoring of the immunosuppression level in a patient with toxic epidermal necrolysis: A case report
| Autor: | Ivan Suchánek, Hana Řihová, Milena Matejovičová, Lucie Novotná, M. Štikarovská, Miroslava Hlaváčová, Hana Paulová, Pavel Brychta, Břetislav Lipový |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
DNA damage medicine.medical_treatment Scars 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine lcsh:Dermatology Medicine Autoimmune disease integumentary system business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid Immunosuppression General Medicine lcsh:RC86-88.9 lcsh:RL1-803 medicine.disease Dermatology Toxic epidermal necrolysis 3. Good health Comet assay 030220 oncology & carcinogenesis Immunology medicine.symptom business |
| Zdroj: | Burns Open, Vol 1, Iss 2, Pp 80-83 (2017) |
| ISSN: | 2468-9122 |
| Popis: | Toxic epidermal necrolysis (TEN) represents the most serious affection within the SCARs group (Severe Cutaneous Adverse Reactions). It is an autoimmune disease manifested by extensive epidermal and mucosal exfoliation. The basic approach in the therapy of patients suffering from toxic epidermal necrolysis is the administration of immunosuppressive medications. Comet assay is a fast, sensitive and relatively easy method used to detect DNA damage levels. We present a case report of a woman with toxic epidermal necrolysis treated with cyclosporine A. During the therapy, comet assay was used to detect the level of DNA damage of circulating lymphocytes and it helped us to reveal qualitative abnormalities in these cells. Keywords: Toxic epidermal necrolysis, Immunosuppression, Comet assay |
| Databáze: | OpenAIRE |
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