Atherosclerosis in Chronic Kidney Disease: Lessons Learned from Glycation in Diabetes
| Autor: | Michael J. Domanski, Jagat Narula, Dilbahar Mohar, Ailin Barseghian, Neena B. Haider |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Glycation End Products
Advanced medicine.medical_specialty Inflammatory response Fluorescent Antibody Technique Diabetes Complications Extracellular matrix Risk Factors Glycation Internal medicine Diabetes mellitus medicine Humans business.industry General Medicine Atherosclerosis Lipid Metabolism medicine.disease Plaque Atherosclerotic Lipoproteins LDL Atheroma Endocrinology Chronic Disease Posttranslational modification Carbohydrate Metabolism Kidney Diseases Inflammation Mediators Tunica Intima business Oxidation-Reduction Lipoprotein Kidney disease |
| Zdroj: | Medical Clinics of North America. 96:57-65 |
| ISSN: | 0025-7125 |
| Popis: | In diabetes, glycation is a nonenzymatic posttranslational modification resulting from the bonding of a sugar molecule with a protein or lipid followed by oxidation, resulting in the development of advanced glycation end products (AGE). Like glycation, carbamylation is a posttranslational protein modification that is associated with AGE formation. Glycation of extracellular matrix proteins and low-density lipoprotein with subsequent deposition in the vessel wall could contribute to inflammatory response and atheroma formation. It is logical to extrapolate that carbamylation may result in modification of vessel wall proteins similar to glycation, and predispose to atherosclerosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|