Pathogenesis of subcortical visuo-spatial neglect. A HMPAO SPECT study
| Autor: | Willy Serniclaes, Claude Hublet, Jacques Paternot, Catherine Colson, Guy Demeurisse |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Cognitive Neuroscience media_common.quotation_subject Experimental and Cognitive Psychology Neurological disorder Brain mapping Neglect Central nervous system disease Behavioral Neuroscience Technetium Tc 99m Exametazime Oximes medicine Humans Attention Dominance Cerebral Stroke Diaschisis media_common Aged Aged 80 and over Cerebral Cortex Tomography Emission-Computed Single-Photon Brain Mapping Neuropsychology Organotechnetium Compounds Middle Aged medicine.disease Cerebrovascular Disorders Cerebral blood flow Regional Blood Flow Female Psychology Neuroscience Psychomotor Performance |
| Zdroj: | Neuropsychologia. 35(5) |
| ISSN: | 0028-3932 |
| Popis: | The pathophysiology of neuropsychological disorders due to right deep-seated hemispheric lesions remains a debated point. We undertook this study to check the hypothesis according to which remote cortical dysfunction could be responsible for the occurrence of neglect. Twenty-eight patients presenting with a right-sided subcortical stroke were studied. A neuropsychological battery of tests suitable for assessment of possible visuo-spatial neglect was performed as well as HMPAO SPECT. Neglect was observed in 15 cases out of 28. The lesion's site (at CT and/or MRI) did not allow discrimination between patients without neglect and patients with neglect. The latter however could be distinguished from the former by the presence of a remote decrease in cortical blood flow in the right temporo-parietal region. By suggesting that cortical involvement is necessary for the occurrence of neglect, the results were interpreted according to a network approach in which subcortical neglect is attributed to a cortical deprivation from afferent input in the posterior part of the brain. |
| Databáze: | OpenAIRE |
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