Preparation of fluorophore-tagged polymeric drug delivery vehicles with multiple biological stimuli-triggered drug release
| Autor: | Na Wang, Xian-Ling Yang, Jun Li, Wan-Xia Wu, Yan-Hong Liu, Xiao-Qi Yu |
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| Rok vydání: | 2019 |
| Předmět: |
Fluorophore
Materials science Polymers Swine Proton Magnetic Resonance Spectroscopy Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Micelle Polyethylene Glycols Biomaterials chemistry.chemical_compound Mice Drug Delivery Systems Cell Line Tumor Stilbenes Copolymer Animals Humans Cytotoxicity Micelles Fluorescent Dyes Cell Death 021001 nanoscience & nanotechnology Controlled release Endocytosis 0104 chemical sciences Drug Liberation RAW 264.7 Cells Spectrometry Fluorescence chemistry Mechanics of Materials Drug delivery Cancer cell Biophysics 0210 nano-technology Ethylene glycol |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 108 |
| ISSN: | 1873-0191 |
| Popis: | In the field of drug delivery, the controlled release of drugs is continuously one of the highly prioritized research domains. Stimuli-responsive polymers are being investigated as drug delivery vehicles that modulate pharmaceutical effect via tumor specific mechanisms. In this work, a biocompatible graft copolymer (denoted as PSNC-g-mPEG/TPE) was constructed, which comprised a triple-responsive polycarbonate backbone coupled with fluorescent TPE and hydrophilic methoxypoly(ethylene glycol) (mPEG) segments. This multifunctional amphiphilic copolymer was able to self-assemble in aqueous solutions and acted as a drug delivery vehicle that releases cargo in response to multiple biological stimuli (ROS, pH and enzymes). And the results of confocal laser scanning microscopy (CLSM) suggested that these micelles could be rapidly internalized by cells and achieve more effective drug release in cancer cells. Furthermore, the cytotoxicity assays proved the safety of this material. It is anticipated that this strategy has enormous potential in constructing novel anticancer therapeutics. |
| Databáze: | OpenAIRE |
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