MYC protein expression is associated with poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system
| Autor: | Gustavo Tapia, Ruth Marginet-Flinch, Aurelio Ariza, Maria Joao Baptista, Jose Luis Mate, Carolina Sanz, Josep-Maria Ribera, Maria Puente-Pomposo, Juan-Manuel Sancho, Olga García, Ana M. Muñoz-Mármol, Ayman Gaafar, José-Tomás Navarro |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Adult Central Nervous System Male Central nervous system Chromosomal translocation Biology Pathology and Forensic Medicine Immunophenotyping Proto-Oncogene Proteins c-myc immune system diseases hemic and lymphatic diseases medicine Immunology and Allergy Humans neoplasms Gene In Situ Hybridization Fluorescence Retrospective Studies General Medicine medicine.disease BCL6 Prognosis Immunohistochemistry Lymphoma DNA-Binding Proteins medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Cancer research Proto-Oncogene Proteins c-bcl-6 Female Lymphoma Large B-Cell Diffuse Diffuse large B-cell lymphoma Follow-Up Studies |
| Zdroj: | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 123(7) |
| ISSN: | 1600-0463 |
| Popis: | MYC and BCL2 gene translocations and protein expression have recently demonstrated to be of prognostic significance in systemic diffuse large B-cell lymphoma (DLBCL). However, their role in primary central nervous system DLBCL (CNS-DLBCL) prognosis has been scarcely analyzed. We studied the immunophenotype, the status of the MYC, BCL2, and BCL6 genes and the clinical features of a series of 42 CNS-DLBCL and evaluated their prognostic significance. We found high MYC protein expression in 43% of cases, and this was associated with lower overall survival (OS). Cases with concurrent expression of MYC and BCL2 showed a lower OS, although the difference did not reach statistical significance. Translocations involving the MYC or BCL2 genes were not detected. The BCL6 gene was frequently translocated, but was unrelated to survival. We conclude that MYC protein expression detected by immunohistochemistry identifies a CNS-DLBCL subset with worse prognosis and may contribute to a more accurate risk stratification of CNS-DLBCL patients. |
| Databáze: | OpenAIRE |
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