Evaluation of the First Commercial Hepcidin ELISA for the Differential Diagnosis of Anemia of Chronic Disease and Iron Deficiency Anemia in Hospitalized Geriatric Patients
| Autor: | Etienne Joosten, Pieter Vermeersch, Inge Geerts |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
biology Article Subject business.industry Anemia nutritional and metabolic diseases medicine.disease Gastroenterology Elisa kit Iron-deficiency anemia Older patients Hepcidin Internal medicine hemic and lymphatic diseases Immunology biology.protein medicine Iron status Differential diagnosis business Anemia of chronic disease Research Article |
| Zdroj: | ISRN Hematology |
| DOI: | 10.5402/2012/567491 |
| Popis: | Introduction. Anemia is a frequent problem in hospitalized geriatric patients, and the anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the 2 most prevalent causes. The aim of the study was to assess the possible role of serum hepcidin in the differential diagnosis between ACD and IDA. Methods. We investigated serum hepcidin, iron status, anemia, and C-reactive protein in 39 consecutive geriatric patients with ACD and IDA. Serum hepcidin levels were determined using a commercial ELISA kit (DRG Instruments, Marburg, Germany). We also measured hepcidin in 26 healthy controls. Results. The serum hepcidin levels were not significantly higher in the 28 patients with ACD as compared to the 11 patients with IDA. Conclusions. The serum hepcidin levels measured using the commercial ELISA kit (DRG) do not appear to increase in older patients with ACD. It should be noted that an assay-specific problem could explain our results. |
| Databáze: | OpenAIRE |
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