Simultaneous determination of anti-diabetes/anti-obesity drugs by LC/PDA, and targeted analysis of sibutramine analog in dietary supplements by LC/MS/MS
| Autor: | Dongmi Choi, Sung Won Kwon, So Hyun Kim, Jangduck Choi, Taehyung Yoon, Deukjoon Kim, Jeongmi Lee |
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| Rok vydání: | 2009 |
| Předmět: |
Clinical Biochemistry
Phenformin Pharmacology Biochemistry Analytical Chemistry chemistry.chemical_compound Tandem Mass Spectrometry Drug Discovery medicine Hypoglycemic Agents Gliclazide Ephedrine Molecular Biology Adulterant Chromatography General Medicine Glimepiride chemistry Dietary Supplements Anti-Obesity Agents Rosiglitazone Cyclobutanes Chromatography Liquid medicine.drug Sibutramine Glipizide |
| Zdroj: | Biomedical Chromatography. 23:1259-1265 |
| ISSN: | 1099-0801 0269-3879 |
| DOI: | 10.1002/bmc.1248 |
| Popis: | The safety of dietary supplements is questionable as there have been occasional reports of products contaminated with illegal adulterants. The present study was carried out to develop trustworthy methodologies to screen for six anti-diabetic drugs (phenformin, rosiglitazone, glipizide, glimepiride, glybenclamide and gliclazide) and six anti-obesity drugs (ephedrine, fenfluramine, T3, T4, fluoxetine and sibutramine) in dietary supplements. A simultaneous determination method of the 12 drugs by liquid chromatography coupled with a photodiode array (LC/PDA) was established and was validated for linearity (r(2) > 0.99), precision (RSD |
| Databáze: | OpenAIRE |
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