Bone mineral density in women with polycystic ovary syndrome
| Autor: | Natalia Ignaszak, Sylwia Sławek, Katarzyna Paczkowska, Natalia Podkowa, Blazej Meczekalski, Krzysztof Katulski, Agnieszka Podfigurna-Stopa, Adam Czyzyk |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism Bone remodeling Z-Score’ hyperandrogenism Young Adult Testosterone blood Endocrinology Bone Density Internal medicine medicine Humans Insulin Testosterone Young adult Bone mineral Lumbar Vertebrae Insulin blood business.industry Polycystic ovary syndrome (PCOS) nutritional and metabolic diseases Luteinizing Hormone HOMA–IR medicine.disease Polycystic ovary female genital diseases and pregnancy complications Original Article Female Follicle Stimulating Hormone business Bone mineral density (BMD) Biomarkers hormones hormone substitutes and hormone antagonists Polycystic Ovary Syndrome Hormone |
| Zdroj: | Journal of Endocrinological Investigation |
| ISSN: | 1720-8386 |
| Popis: | Purpose PCOS is a complex disorder and various features of this disorder may have great importance for bone metabolism. The aim of the study was to determine the relationship between existing hormonal disorders, and bone mineral density (BMD) in young women with PCOS. Methods 69 reproductive-aged PCOS women and 30 age-matched healthy controls were enrolled to the study women. In each individual we assessed the body mass index (BMI). We evaluated the serum concentrations of: gonadotropins, prolactin (PRL), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS), testosterone (T), thyroid stimulating hormone (TSH), free thyroxine (fT4). We used the Homeostatic Model Assessment–Insulin Resistance Index (HOMA–IR) to diagnose insulin resistance. Bone mineral density in the lumbar spine was measured by dual-energy X-ray absorptiometry (DXA). Results The PCOS women had lower BMD values as compared to the controls (1.057 ± 0.1260 vs. 1.210 ± 0.1805 g/cm2, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink