Telomere length, arsenic exposure and risk of basal cell carcinoma of skin
| Autor: | Tony Fletcher, Nalini Srinivas, Peter Rudnai, Thomas Hielscher, Rajesh Kumar, Eugene Gurzau, Silvia Calderazzo, Kvetoslava Koppova, Sivaramakrishna Rachakonda |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Cancer Research Skin Neoplasms Physiology chemistry.chemical_element Polymorphism Single Nucleotide Arsenic 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Genetic Predisposition to Disease Basal cell carcinoma ARSENIC EXPOSURE Aged integumentary system Arsenic toxicity business.industry Case-control study Environmental Exposure General Medicine Odds ratio Environmental exposure Middle Aged Telomere medicine.disease Increased risk Endocrinology 030104 developmental biology chemistry Carcinoma Basal Cell Case-Control Studies 030220 oncology & carcinogenesis Female Skin cancer business |
| Zdroj: | Carcinogenesis. 40:715-723 |
| ISSN: | 1460-2180 0143-3334 |
| Popis: | Telomere length per se a heritable trait has been reported to be associated with different diseases including cancers. In this study based on arsenic exposed 528 cases with basal cell carcinoma of skin (BCC) and 533 healthy controls, we observed a statistically significant association between decreased telomere length and increased BCC risk (OR = 5.92, 95% CI = 3.92-9.01, P1.32 µg/L) was statistically significantly associated with decreased telomere length (β = −0.026, 95% CI = − 0.05-0.003, P = 0.02). The interaction between arsenic exposure and telomere length on BCC risk was statistically significant (P = 0.02). Within each tertile based on arsenic exposure, the individuals with shorter telomeres were at an increased risk of BCC, with highest risk being in the highest exposed group (OR = 16.13, 95% CI = 6.71-40.00, PP P = 0.0002). The combined effect of highest arsenic exposure and shortest telomeres on the risk of BCC (OR = 10.56, 95% CI = 5.14-21.70) showed a statistically significant departure from additivity (interaction constant ratio 6.56, P = 0.03). Our results show that in the presence of arsenic exposure, decreased telomere length predisposes individuals to increased risk of BCC, with the effect being synergistic in individuals with highest arsenic exposure and shortest telomeres. |
| Databáze: | OpenAIRE |
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