Strategies for the synthesis of brevipolides
Autor: | A'liyatur Rosyidah, Yudhi Dwi Kurniawan |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
biology
5 6-dihydro-α-pyrone Chemokine receptor CCR5 Chemistry brevipolides Science Organic chemistry Review Computational biology Hyptis brevipes biology.organism_classification ring-closing metathesis QD241-441 furukawa-modified simmons–smith cyclopropanation biology.protein hyptis brevipes poit Cytotoxicity Human cancer |
Zdroj: | Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 2399-2416 (2021) Beilstein Journal of Organic Chemistry |
ISSN: | 1860-5397 |
Popis: | In recent years fifteen 5,6-dihydro-α-pyrone derivatives, bearing either a distinctive cyclopropane or furan ring and named brevipolides A–O (1–15), have been isolated from the invasive plant Hyptis brevipes Poit. Their fascinating structural features, and the potent biological activities, including cytotoxicity against an array of human cancer cell lines and inhibition of the chemokine receptor CCR5, make them attractive synthetic targets. This review article highlights the recent synthetic methodologies and briefly summarizes their biological activities. |
Databáze: | OpenAIRE |
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