Alkyl-Terminated Gold Nanoparticles as a Self-Therapeutic Treatment for Psoriasis
| Autor: | Qianqian Bai, Chung Hang Jonathan Choi, Paul Cheung-Lung Choi, Cecilia Ka Wing Chan, Leo Kit Cheung Lee, Ruifang Han, Lok Wai Cola Ho |
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| Rok vydání: | 2021 |
| Předmět: |
Keratinocytes
Metal Nanoparticles Excipient Nanoparticle Bioengineering Imiquimod Polyethylene glycol Pharmacology Mice chemistry.chemical_compound Psoriasis medicine Stratum corneum Animals General Materials Science integumentary system Epidermis (botany) Mechanical Engineering General Chemistry Condensed Matter Physics medicine.disease Disease Models Animal medicine.anatomical_structure chemistry Colloidal gold Nanoparticles Gold medicine.drug |
| Zdroj: | Nano Letters. 21:8723-8733 |
| ISSN: | 1530-6992 1530-6984 |
| Popis: | We present a self-therapeutic nanoparticle for topical delivery to epidermal keratinocytes to prevent and treat psoriasis. Devoid of known chemical or biological antipsoriatic drugs, this sub-15 nm nanoparticle contains a 3 nm gold core and a shell of 1000 Da polyethylene glycol strands modified with 30% octadecyl chains. When it is applied to imiquimod-induced psoriasis mice without an excipient, the nanoparticle can cross the stratum corneum and preferentially enter keratinocytes. Applying the nanoparticles concurrently with imiquimod prevents psoriasis and downregulates genes that are enriched in the downstream of the interleukin-17 signaling pathway and linked to epidermis hyperproliferation and inflammation. Applying the nanoparticles after psoriasis is established treats the psoriatic skin as effectively as standard steroid and vitamin D analog-based therapy but without hair loss and skin wrinkling. The nanoparticles do not accumulate in major organs or induce long-term toxicity. Our nanoparticle offers a simple, safe, and effective alternative for treating psoriasis. |
| Databáze: | OpenAIRE |
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