Genetic and physical mapping of the CLN6 gene on chromosome 15q21-23
| Autor: | Ruth E Williams, Brian D. Lake, JD Sharp, RM Gardiner, M Fox, RB Wheeler |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism Biology Biochemistry Endocrinology Neuronal Ceroid-Lipofuscinoses Genetics Humans Molecular Biology Gene Alleles Gene Library Sequence Tagged Sites Chromosomes Human Pair 15 Transcript mapping Chromosome Chromosome Mapping Disease gene identification Physical Chromosome Mapping Pedigree Phenotype Haplotypes Genetic marker Physical mapping Female Late infantile neuronal ceroid lipofuscinosis Microsatellite Repeats |
| Zdroj: | Molecular genetics and metabolism. 66(4) |
| ISSN: | 1096-7192 |
| Popis: | CLN6, the gene for a variant late infantile neuronal ceroid lipofuscinosis, has been mapped to chromosome 15q21–23 by homozygosity mapping. At present the family resource consists of 31 families. By the analysis of additional polymorphic markers in this resource the critical region has been narrowed down from 12 cM to less than 4 cM. A physical map is being constructed using YAC and PAC clones as a prerequisite to transcript mapping. |
| Databáze: | OpenAIRE |
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