Genomic and phylogenetic characterisation of an imported case of SARS-CoV-2 in Amazonas State, Brazil
| Autor: | Fernanda Nascimento, Débora Duarte, Ágatha Costa, André de Lima Guerra Corado, Edson Delatorre, Valdinete Alves do Nascimento, Sérgio Luiz Bessa Luz, Luciana Mara Fé Gonçalves, Michele Silva de Jesus, Cristiano Fernandes da Costa, Felipe Gomes Naveca |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Lineage (genetic) viruses Short Communication RC955-962 030231 tropical medicine Pneumonia Viral coronavirus Genomics Genome Viral Biology medicine.disease_cause Microbiology Genome 03 medical and health sciences Betacoronavirus 0302 clinical medicine Phylogenetics Arctic medicine. Tropical medicine medicine Amazon Region Humans skin and connective tissue diseases genome Asymptomatic Infections Pandemics Phylogeny Coronavirus Whole genome sequencing Phylogenetic tree SARS-CoV-2 virus diseases COVID-19 biology.organism_classification QR1-502 Phylogeography Evolutionary biology Spain Mutation Coronavirus Infections Brazil |
| Zdroj: | Memórias do Instituto Oswaldo Cruz Memórias do Instituto Oswaldo Cruz., Vol 115 (2020) Memórias do Instituto Oswaldo Cruz, Volume: 115, Article number: e200310, Published: 25 SEP 2020 |
| ISSN: | 1678-8060 0074-0276 |
| Popis: | A new coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] is currently causing a life-threatening pandemic. In this study, we report the complete genome sequencing and genetic characterisation of a SARS-CoV-2 detected in Manaus, Amazonas, Brazil, and the protocol we designed to generate high-quality SARS-CoV-2 full genome data. The isolate was obtained from an asymptomatic carrier returning from Madrid, Spain. Nucleotide sequence analysis showed a total of nine mutations in comparison with the original human case in Wuhan, China, and support this case as belonging to the recently proposed lineage A.2. Phylogeographic analysis further confirmed the likely European origin of this case. To our knowledge, this is the first SARS-CoV-2 genome obtained from the North Brazilian Region. We believe that the information generated in this study may contribute to the ongoing efforts toward the SARS-CoV-2 emergence. |
| Databáze: | OpenAIRE |
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