Bioavailability and in vivo metabolism of intact glucosinolates
| Autor: | Hilmer Sørensen, Heidi Blok Frandsen, Jens Christian Sørensen, Niels Bastian Kristensen, Susanne Sørensen, Søren Krogh Jensen |
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| Rok vydání: | 2016 |
| Předmět: |
Metabolite
Glucuronidation Medicine (miscellaneous) Urine Biology 010402 general chemistry 01 natural sciences Hepatic vein Absorption Excretion chemistry.chemical_compound Phase II enzymes digestive system TX341-641 Nutrition and Dietetics Nutrition. Foods and food supply Cruciferous vegetables 010401 analytical chemistry Glucosinolate 0104 chemical sciences Bioavailability Sinalbin Digestive system chemistry Biochemistry Hepatic Vein Phase II enzyms absorption Food Science |
| Zdroj: | Sørensen, J C, Frandsen, H B, Jensen, S K, Kristensen, N B, Sørensen, S & Sørensen, H 2016, ' Bioavailability and in vivo metabolism of intact glucosinolates ', Journal of Functional Foods, vol. 24, pp. 450-460 . https://doi.org/10.1016/j.jff.2016.04.023 Journal of Functional Foods, Vol 24, Iss, Pp 450-460 (2016) |
| ISSN: | 1756-4646 |
| Popis: | Health benefits associated with consumption of cruciferous vegetables have received considerable attention with a hitherto focus on the role and bioactivity of glucosinolate degradation products. We investigated the in vivo metabolism of intact glucosinolates by following their fate in digesta and in the endogenous metabolism in pigs. This is the first study to show an intact glucosinolate, sinalbin, being absorbed and transformed to a sinalbin metabolite in the liver by glucuronidation expectedly performed by liver phase II enzymes with subsequent excretion to the urine. From LC–MS/MS data we propose a structure of the sinalbin metabolite as containing two 4-oxybenzyl groups. Sinalbin and the metabolite were detected in plasma from the hepatic vein with a ratio of metabolite to sinalbin of approximately 12:1 after 2–4 hours. Induction of liver phase II enzymes by intact glucosinolates indicates that these also themselves are bioactive compounds with potential health risks or beneficial effects. |
| Databáze: | OpenAIRE |
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