The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo
| Autor: | Christine Brennan, Story C. Landis, Kimberly Rivas-Plata |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Genetically modified mouse
medicine.medical_specialty animal structures Cell Count Mice Transgenic Receptors Nerve Growth Factor Tropomyosin receptor kinase A Receptor Nerve Growth Factor Mice Neurotrophin 3 In vivo Internal medicine medicine Animals Low-affinity nerve growth factor receptor Nerve Growth Factors Alleles Neurons Ganglia Sympathetic biology General Neuroscience Adaptation Physiological medicine.anatomical_structure Nerve growth factor Endocrinology Animals Newborn nervous system biology.protein sense organs Neuron Neuroscience Neurotrophin |
| Zdroj: | Nature Neuroscience. 2:699-705 |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | To determine the role of the p75 neurotrophin receptor (p75NTR) in sympathetic neuron development, we crossed transgenic mice with mutations in p75NTR, nerve growth factor (NGF) and neurotrophin-3 (NT-3). Neuron number is normal in sympathetic ganglia of adult p75NTR-/- mice. Mice heterozygous for a NGF deletion (NGF+/-) have 50% fewer sympathetic neurons. In the absence of p75NTR (p75NTR-/- NGF+/-), however, neuron number is restored to wild-type levels. When NT-3 levels are reduced (p75NTR-/- NGF+/- NT3 +/-), neuron number decreases compared to p75NTR-/- NGF+/- NT3+/+. Thus, without p75NTR, NT3 substitutes for NGF, suggesting that p75 alters the neurotrophin specificity of TrkA in vivo. |
| Databáze: | OpenAIRE |
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