Treatment of AIDS-related primary central nervous system lymphoma with zidovudine, ganciclovir, and interleukin 2
| Autor: | Ernesto G. Scerpella, Gerald E. Byrne, Lisa Cabral, Judith Hurley, George Sfakianakis, Jian Ping Cai, Howard Landy, Luis E. Raez, Dushyantha Jayaweera, William J. Harrington |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Ganciclovir
Adult Male medicine.medical_specialty Adolescent Anti-HIV Agents medicine.medical_treatment Immunology AIDS-related complex Apoptosis Gastroenterology Central nervous system disease Zidovudine hemic and lymphatic diseases Virology Internal medicine medicine Tumor Cells Cultured Humans Lymphoma AIDS-Related Chemotherapy business.industry Brain Neoplasms Primary central nervous system lymphoma medicine.disease Lymphoma Regimen Infectious Diseases Treatment Outcome Interleukin-2 Drug Therapy Combination Female business medicine.drug |
| Zdroj: | AIDS research and human retroviruses. 15(8) |
| ISSN: | 0889-2229 |
| Popis: | AIDS-related primary central nervous system lymphoma (AIDS PCNSL) is a rapidly fatal disease. Conventional therapeutic modalities offer little and new approaches are needed. Previous work has shown that zidovudine (AZT) in combination with other agents is active in retroviral lymphomas. Epstein-Barr virus (EBV) is detected in tumor tissue and cerebrospinal fluid of AIDS PCNSL patients. In a preliminary in vitro study we found that an Epstein-Barr virus-positive B cell line underwent apoptosis on coculture with AZT. This effect was accentuated by the addition of ganciclovir (GCV). We treated five patients with AIDS PCNSL with a regimen consisting of parenteral zidovudine (1.6 g twice daily), ganciclovir (5 mg/kg twice daily), and interleukin 2 (2 million units twice daily). Four of five had an excellent response. Two patients are alive and free of disease 22 and 13 months later; another responded on two separate occasions, 5 months apart, and the last patient responded with a 70-80% regression of tumor but could not be maintained on therapy owing to myelosuppression. We conclude that parenteral zidovudine, ganciclovir, and interleukin 2 is an active combination for AIDS-related central nervous system lymphoma. |
| Databáze: | OpenAIRE |
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