Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain
| Autor: | Takayo Sasagawa, Noriko Horii-Hayashi, Wataru Matsunaga, Mayumi Nishi |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Article Subject Hypothalamus Hippocampus Biology Somatosensory system Amygdala lcsh:RC321-571 Extracellular matrix Mice Limbic system Limbic System medicine Animals lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Neurons Perineuronal net Chondroitin Sulfates Brain Extracellular Matrix Mice Inbred C57BL medicine.anatomical_structure Chondroitin Sulfate Proteoglycans nervous system Neurology Synaptic plasticity Reticular connective tissue Neurology (clinical) Neuroscience Brain Stem Research Article |
| Zdroj: | Neural Plasticity, Vol 2015 (2015) Neural Plasticity |
| ISSN: | 1687-5443 2090-5904 |
| DOI: | 10.1155/2015/256389 |
| Popis: | Chondroitin sulfate proteoglycans (CSPGs) are major components of the extracellular matrix (ECM) in the brain. In adult mammals, CSPGs form the specialized ECM structure perineuronal nets (PNNs) that surround somata and dendrites of certain types of neurons. PNNs restrict synaptic plasticity and regulate the closure of critical periods. Although previous studies have examined the starting period of PNN formation, focusing on primary sensory cortices, there are no systematic studies at the whole brain level. Here, we examined the starting period of PNN formation in male mice ranging in age from postnatal day 3 to week 11, mainly focusing on several cortical areas, limbic structures, hypothalamus, and brain stem, using lectin histochemistry withWisteria floribundaagglutinin (WFA). Results showed that early PNN formation was observed in several reticular formations of the brain stem related to the cranial nerves and primary somatosensory cortices. In the limbic system, PNN formation in the hippocampus started earlier than that of the amygdala. Furthermore, in the medial amygdaloid nucleus and some hypothalamic regions, WFA labeling did not show typical PNN-like forms. The present study suggests spatiotemporal differences at the beginning of PNN formation and a structural variety of CSPG-contained ECM in the brain. |
| Databáze: | OpenAIRE |
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