Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II)

Autor: Leclercq, Christophe, Burri, Haran Kumar, Curnis, Antonio, Delnoy, Peter Paul, Rinaldi, Christopher A, Sperzel, Johannes, Lee, Kwangdeok, Cohorn, Clay, Thibault, Bernard, MORE-CRT MPP Investigators
Přispěvatelé: CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Geneva [Switzerland], Università degli Studi di Brescia [Brescia], King's College Hospital (KCH), Kerckhoff-Klinik, Université de Montréal (UdeM), AbbottAbbott, Université de Genève = University of Geneva (UNIGE), Università degli Studi di Brescia = University of Brescia (UniBs)
Rok vydání: 2017
Předmět:
Male
Time Factors
genetic structures
medicine.medical_treatment
biventricular pacing
030204 cardiovascular system & hematology
Ventricular Function
Left
law.invention
Cardiac Resynchronization Therapy
0302 clinical medicine
Randomized controlled trial
law
randomized trial
Ventricular Function
030212 general & internal medicine
Prospective Studies
ddc:616
Ventricular Remodeling
Heart Failure/physiopathology/therapy
Left/physiology
left ventricular lead
multipoint pacing
cardiac resynchronization
3. Good health
Treatment Outcome
cardiovascular system
Cardiology
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Female
Cardiology and Cardiovascular Medicine
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
circulatory and respiratory physiology
medicine.medical_specialty
Cardiac resynchronization therapy
03 medical and health sciences
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Internal medicine
medicine
Cardiac Resynchronization Therapy/methods
Humans
In patient
cardiovascular diseases
Reverse remodeling
Aged
Heart Failure
business.industry
Stroke Volume
equipment and supplies
medicine.disease
Multicenter study
Stroke Volume/physiology
Heart failure
Implant
business
Follow-Up Studies
Zdroj: American Heart Journal
American Heart Journal, Elsevier, 2019, 209, pp.1-8. ⟨10.1016/j.ahj.2018.12.004⟩
American Heart Journal, 2019, 209, pp.1-8. ⟨10.1016/j.ahj.2018.12.004⟩
American Heart Journal, Vol. 209 (2019) pp. 1-8
ISSN: 1097-6744
0002-8703
Popis: International audience; BACKGROUND: Although cardiac resynchronization therapy (CRT) is beneficial in most heart failure patients, up to 40% do not respond to CRT. Data from the MultiPoint Pacing (MPP) IDE trial and MORE-CRT MPP-PHASE I study suggest improved response in subjects in the MPP arm-programmed with wide left ventricular (LV) electrode anatomical separation (≥30 mm) and shortest timing delays of 5 milliseconds (MPP-AS)-compared with quadripolar biventricular (BiV) pacing.STUDY DESIGN: The MORE-CRT MPP-PHASE II trial is a prospective, randomized, multicenter study to assess the 6-month impact of MPP programmed to mandated MPP-AS settings in subjects who do not respond to 6 months of BiV pacing (MPP OFF). Approximately 5,000 subjects with a standard CRT indication will be enrolled and implanted with a quadripolar CRT system (Abbott) capable of delivering MPP. Only BiV pacing is activated at implant. At 6 months, subjects classified as CRT nonresponders (
Databáze: OpenAIRE
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