Cytokines profile in serum of homozygous familial hypercholesterolemia is changed by LDL-apheresis

Autor: Claudia Stefanutti, A. Vivenzio, S. Di Giacomo, Pietro Manuel Ferraro
Rok vydání: 2011
Předmět:
Adult
Male
medicine.medical_specialty
Adolescent
Lipoproteins
Immunology
dextran sulphate cellulose ldl-apheresis
Homozygous familial hypercholesterolemia
Inflammation
Familial hypercholesterolemia
Biochemistry
Receptors
Tumor Necrosis Factor
LDL
Aortic valvular disease
Hyperlipoproteinemia Type II
Young Adult
Limit of Detection
Internal medicine
Receptors
LDL-apheresis
medicine
Settore MED/14 - NEFROLOGIA
Humans
Immunology and Allergy
Child
Molecular Biology
Vascular Endothelial Growth Factor Receptor-1
business.industry
Cholesterol
LDL
Hematology
Atherosclerosis
medicine.disease
Lipoproteins
LDL
Cholesterol
Endocrinology
Apheresis
Dextran sulphate
LDL apheresis
Cytokines
Female
Blood Component Removal
cytokines
inflammation
ldl-apheresis
atherosclerosis
homozygous familial hypercholesterolemia
Tumor necrosis factor alpha
medicine.symptom
Tumor Necrosis Factor
business
Zdroj: Cytokine. 55:245-250
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2011.04.003
Popis: Objective The effects of LDL-apheresis (LDLa) with dextran sulphate on plasma cytokines in 6 homozygous familial hypercholesterolemic (HozFH) patients, were evaluated. Methods Plasma IL-1α; IL-1ra; IL-4; IL-6; IL-10; IL-12(p40); IL-12(p70); TNF-α, sTNF-R, VEGF, VEGF-R1, E-Selectin (ESEL), and P-Selectin (PSEL) concentrations were measured before and after LDLa on three consecutive sessions for each patient. Results TNF-α was significantly reduced (−60%; P = 0.01), while TNF-R was only slightly increased (+15%), although not significantly. Plasma VEGF was significantly reduced (−57%; P = 1.87301E−05), while VEGF-R1 was significantly increased (+56%; P = 0.05). ESEL and PSEL were reduced but not to a statistically significant extent (−19%, −15%, respectively). IL-1α level was dramatically reduced (−87%; P = 0.0001). IL-1ra concentration was only slightly increased in plasma, but not significantly. IL-4 and IL-10 levels were significantly reduced in plasma after apheresis (−50%; P = 0.03, and −55%; P = 0.004, respectively). On the contrary, IL-6 concentration showed a slight decrease (−8%). Plasma IL-12p40 was significantly increased (+47%; P = 0.0004). On the other hand, IL-12p70 was reduced, but the difference (−31%) was not statistically significant. Conclusions Plasma cytokines imbalance is associated with inflammation and atherogenesis. In this study LDLa changed several circulating cytokines inducing anti-inflammatory and anti-atherogenic changes in cytokines plasma profile in HozFH patients with/without pre-existing angiographically demonstrated coronary heart disease (CHD) and aortic valvular disease (AVD).
Databáze: OpenAIRE
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