COAGULATION DEFECTS AND ATHEROSCLEROSIS INDUCED IN RABBITS BY A DIET CONTAINING MEDIUM CHAIN TRIGLYCERIDES (MCT)
| Autor: | Gösta Arvidson, Inger Kockum, Nils H. Sternby, Inga Marie Nilsson, Haqvin Malmros |
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| Rok vydání: | 2009 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Time Factors Cirrhosis Malabsorption Arteriosclerosis Linoleic acid Adipose tissue Blood lipids Fatty Acids Nonesterified Zea mays chemistry.chemical_compound Internal medicine Internal Medicine medicine Animals Blood Coagulation Aorta Triglycerides Blood coagulation test Triglyceride business.industry Myocardium Blood Coagulation Disorders medicine.disease Coronary Vessels Lipids Cholesterol Endocrinology Adipose Tissue Linoleic Acids Liver chemistry Diet Atherogenic Blood Coagulation Tests Rabbits business Oils Corn oil |
| Zdroj: | Acta Medica Scandinavica. 192:201-212 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1972.tb04803.x |
| Popis: | In recent years medium chain triglycerides (MCT) have been widely used in the treatment of various diseases, such as different forms of malabsorption and certain types of hyperlipaemia. Only a few animal experimental studies and hardly any long-term studies had been available before the introduction of this agent as a therapeutic in clinical medicine. In experiments on rabbits a semisynthetic diet containing 20% MCT produced a remarkable rise in serum cholesterol, a certain increase of the triglycerides and distinct atheromatous changes in the aorta. The level of linoleic acid decreased markedly in the neutral lipids of serum, liver and adipose tissue. There was also an influence on the relative proportions of saturated and monounsaturated long chain fatty acids in the serum lipids. The phospholipids of serum and liver retained relatively high levels of linoleic acid. An incidental finding was that MCT caused a defect of the coagulation of the same type as that seen in severe diseases of the liver, such as liver cirrhosis in man. At postmortem examination considerable changes were found in the liver, probably a manifestation of a toxic effect. In two cases MCT was replaced by an equivalent amount of corn oil after 32 weeks. This resulted in a rapid normalization of the serum cholesterol and triglyceride values. The coagulation of the blood also became normal. Postmortem examination of these two cases, after they had been fed corn oil for 18 weeks, revealed a normal or practically normal liver. |
| Databáze: | OpenAIRE |
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