High cell surface CD26-associated activities and low plasma adenosine concentration in fibromyalgia
| Autor: | Youlet By, Eric Guedj, Alix Dousset, Régis Guieu, Jean Claude Peragut, Jean Régis, Jean Marc Leveque, Roch Giorgi, Jean Ruf, Veronique Tuzzolino, Emmanuel Fenouillet, Philippe Roussel |
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| Přispěvatelé: | Dysoxie, suractivité : aspects cellulaires et intégratifs thérapeutiques (DS-ACI / UMR MD2), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Service de neurochirurgie fontionnelle et stéréotaxique, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN (NICN), Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Adenosine Fibromyalgia MESH: Analgesics Adenosine Deaminase Endogeny MESH: Pain Measurement 0302 clinical medicine Adenosine deaminase Sickness Impact Profile Immunology and Allergy ComputingMilieux_MISCELLANEOUS Pain Measurement MESH: Adenosine Deaminase 0303 health sciences education.field_of_study Analgesics MESH: Middle Aged biology Middle Aged 3. Good health MESH: Leukocytes Mononuclear MESH: Sickness Impact Profile [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system Female Chronic Pain MESH: Pain Management medicine.drug medicine.medical_specialty Dipeptidyl Peptidase 4 Immunology Population General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Rheumatology Dopamine Internal medicine Extracellular medicine Humans Pain Management education 030304 developmental biology MESH: Fibromyalgia MESH: Humans business.industry medicine.disease MESH: Adenosine MESH: Dipeptidyl Peptidase 4 MESH: Male Endocrinology biology.protein Leukocytes Mononuclear MESH: Chronic Pain Serotonin business MESH: Female 030217 neurology & neurosurgery |
| Zdroj: | Annals of the Rheumatic Diseases Annals of the Rheumatic Diseases, BMJ Publishing Group, 2012, 71 (8), pp.1427-8. ⟨10.1136/annrheumdis-2011-201174⟩ Annals of the Rheumatic Diseases, 2012, 71 (8), pp.1427-8. ⟨10.1136/annrheumdis-2011-201174⟩ |
| ISSN: | 0003-4967 1468-2060 |
| DOI: | 10.1136/annrheumdis-2011-201174⟩ |
| Popis: | The fibromyalgia syndrome (FMS) affects 2%–10% of the population. Its diagnosis is only based on a history of widespread pain involving limbs and trunk and mild or greater tenderness to digital palpation of tender points.1 While the role of several neurotransmitters including serotonin, dopamine and SP has been suggested, the influence of endogenous adenosine has never been investigated. Adenosine exerts strong antinociceptive effects mostly via the activation of A1 adenosine receptors2 following its release by endothelial cells and myocytes3 into the extracellular space where it is degraded by the enzyme adenosine deaminase (ADA). Large amounts of ADA are found at the surface of mononuclear cells … |
| Databáze: | OpenAIRE |
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