mTOR, linking metabolism and immunity
| Autor: | Rafi Ahmed, Lilin Ye, Xiaojin Xu, Koichi Araki |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
B-Lymphocytes
Effector Cellular differentiation T-Lymphocytes TOR Serine-Threonine Kinases Immunology Autophagy RPTOR Immunity Cell Differentiation Biology Article Cell biology Immune system Humoral immunity Immunology and Allergy Animals Humans Signal transduction PI3K/AKT/mTOR pathway Signal Transduction |
| Zdroj: | Seminars in immunology. 24(6) |
| ISSN: | 1096-3618 |
| Popis: | mTOR is an evolutionarily conserved serine/threonine kinase that plays a critical role in cell growth and metabolism by sensing different environmental cues. There is a growing appreciation of mTOR in immunology for its role in integrating diverse signals from the immune microenvironment and coordinating the functions of immune cells and their metabolism. In CD8 T cells, mTOR has shown to influence cellular commitment to effector versus memory programming; in CD4 T cells, mTOR integrates environmental cues that instruct effector cell differentiation. In this review, we summarize and discuss recent advances in the field, with a focus on the mechanisms through which mTOR regulates cellular and humoral immunity. Further understanding will enable the manipulation of mTOR signaling to direct the biological functions of immune cells, which holds great potential for improving immune therapies and vaccination against infections and cancer. |
| Databáze: | OpenAIRE |
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