Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study
| Autor: | Ola Landgren, Bjarni A. Agnarsson, Sigrun Thorsteinsdottir, Sæmundur Rögnvaldsson, Dadi Helgason, Asbjorn Jonsson, Elias Eythorsson, Brian G.M. Durie, Gudrun Kristjansdottir, Pall T. Onundarson, Hlif Steingrimsdottir, Sigurdur Y. Kristinsson, Runolfur Palsson, Gauti Kjartan Gislason, Arnar S Agustsson, Andri Olafsson, Aron H. Bjornsson, Ingunn Thorsteinsdottir, Stephen E. Harding, Hrafnhildur Linnet Runolfsdottir, Brynjar Vidarsson, Thorvarður Jon Love, Arna R. Emilsdottir, Petros Kampanis, Olafur S. Indridason, Malin Hultcrantz, Asdis Rosa Thordardottir, Margret Sigurdardottir, Isleifur Olafsson |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Epidemiology Iceland Myeloma Monoclonal Gammopathy of Undetermined Significance Article Cohort Studies Population based cohort immune system diseases hemic and lymphatic diseases Internal medicine medicine Humans RC254-282 Multiple myeloma Aged SARS-CoV-2 business.industry COVID-19 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Hematology Odds ratio Middle Aged medicine.disease Confidence interval Increased risk Risk factors Oncology Infectious diseases Female business Monoclonal gammopathy of undetermined significance Cohort study |
| Zdroj: | Blood Cancer Journal Blood Cancer Journal, Vol 11, Iss 12, Pp 1-6 (2021) |
| ISSN: | 2044-5385 |
| Popis: | Multiple myeloma (MM) patients have increased risk of severe coronavirus disease 2019 (COVID-19) when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monoclonal gammopathy of undetermined significance (MGUS), the precursor of MM has been associated with immune dysfunction which may lead to severe COVID-19. No systematic data have been published on COVID-19 in individuals with MGUS. We conducted a large population-based cohort study evaluating the risk of SARS-CoV-2 infection and severe COVID-19 among individuals with MGUS. We included 75,422 Icelanders born before 1976, who had been screened for MGUS in the Iceland Screens Treats or Prevents Multiple Myeloma study (iStopMM). Data on SARS-CoV-2 testing and COVID-19 severity were acquired from the Icelandic COVID-19 Study Group. Using a test-negative study design, we included 32,047 iStopMM participants who had been tested for SARS-CoV-2, of whom 1754 had MGUS. Among these participants, 1100 participants, tested positive, 65 of whom had MGUS. Severe COVID-19 developed in 230 participants, including 16 with MGUS. MGUS was not associated with SARS-CoV-2 infection (Odds ratio (OR): 1.05; 95% confidence interval (CI): 0.81–1.36; p = 0.72) or severe COVID-19 (OR: 0.99; 95%CI: 0.52–1.91; p = 0.99). These findings indicate that MGUS does not affect the susceptibility to SARS-CoV-2 or the severity of COVID-19. |
| Databáze: | OpenAIRE |
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