miR-155 T/A (rs767649) and miR-146a A/G (rs57095329) single nucleotide polymorphisms as risk factors for chronic hepatitis B virus infection among Egyptian patients

Autor:	Mohammed Abdelhakeem, Rania H. Mahmoud, Noha A. Hassuna, Tebyan A. Abelhameed, Mohamed Masoud, Olfat G. Shaker, Enas M. Hefzy, Nada F. Hemeda, Tarek I Ahmed
Rok vydání:	2021
Předmět:	Male Heredity Epidemiology Single Nucleotide Polymorphisms medicine.disease_cause Gastroenterology Biochemistry law.invention law Risk Factors Genotype Medicine and Health Sciences Polymerase chain reaction Pathology and laboratory medicine education.field_of_study Multidisciplinary Liver Diseases Software Engineering Medical microbiology Nucleic acids Genetic Mapping Viruses Medicine Liver Fibrosis Engineering and Technology Egypt Female Pathogens Research Article Adult medicine.medical_specialty Hepatitis B virus Computer and Information Sciences Science Population Single-nucleotide polymorphism Variant Genotypes Gastroenterology and Hepatology Polymorphism Single Nucleotide Microbiology Virus miR-155 Computer Software Hepatitis B Chronic Internal medicine DNA-binding proteins medicine Genetics Humans Genetic Predisposition to Disease Allele education Non-coding RNA Alleles Genetic Association Studies Natural antisense transcripts business.industry Viral pathogens Organisms Biology and Life Sciences Proteins Hepatitis viruses Gene regulation Regulatory Proteins Microbial pathogens MicroRNAs Gene Expression Regulation Medical Risk Factors RNA Gene expression business Transcription Factors
Zdroj:	PLoS ONE PLoS ONE, Vol 16, Iss 8, p e0256724 (2021)
ISSN:	1932-6203 5709-5329
Popis:	Genetic variants in microRNAs (miRNAs) can alter the miRNAs expression and/or function, accordingly, affecting the related biological pathways and disease risk. Dysregulation of miR-155 and miR-146a expression levels has been well-described in viral hepatitis B (HBV). In the current study, we aimed to assess rs767649 T/A and rs57095329 A/G polymorphisms in miR-155, and miR-146a genes, respectively, as risk factors for Chronic HBV (CHBV) in the Egyptian population. Also, we aimed to do in silico analysis to investigate the molecules that primarily target these miRNAs. One hundred patients diagnosed as CHBV and one hundred age and sex-matched controls with evidence of past HBV infection were genotyped for miR-155 (rs767649) and miR-146a (rs57095329) using real-time polymerase chain reaction. The rs767649 AT and AA genotypes in CHBV patients confer four folds and ten folds risk respectively, as compared to control subjects [(AOR = 4.245 (95%CI 2.009–8.970), pppp = 0.004] and [AOR = 5.604 (95%CI 2.157–14.563), p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bd91cad91ec128a9aa468d4a784e4a https://pubmed.ncbi.nlm.nih.gov/34437653 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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